Synthetic studies on carbohydrate antibiotics. XVIII. Total synthesis of ribostamycin.
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چکیده
منابع مشابه
Synthetic studies on pseudo-dimeric Lycopodium alkaloids: total synthesis of complanadine B.
Complanadines A and B (1 and 2, Scheme 1) are dimeric Lycopodium alkaloids from the lycodine family that possess significant activity for stimulating nerve growth factor (NGF) production in human glial cells. 2] As such, 1 and 2 are of interest as potential small-molecule leads for the treatment of neurodegenerative diseases, such as Alzheimer s disease, as well as adjuvants for the regeneratio...
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A synthetic approach to the tunicamycins, a complex family of nucleosides with potent antibiotic and antiviral activities is reported based on diazo chemistry. The corresponding precursors for the synthesis of tunicaminyl uracil derivatives, the non-stabilized diazo derived from 13 and the aldehyde derivative of uridine, compound 4, were prepared efficiently from commercially available D-galact...
متن کاملSynthetic studies on stevastelins. 1. Total synthesis of stevastelins B and B3.
[Chemical reaction: See text] The synthesis of stevastelin B3 (2) and B (5) are described. In a first approach, epoxy cyclodepsipeptide 8 was considered as a promising candidate for the synthesis of the [15]-membered ring members of the stevastelins; however, the oxirane ring opening, required for the completion of the natural stevastelin synthesis, failed. Thus, we synthesized stevastelin B (5...
متن کاملCarbohydrate-based first stereoselective total synthesis of bioactive cytospolide P.
A facile carbohydrate-based highly stereoselective synthetic route has been developed for the cytospolide P (1) from D-ribose for the first time. Key steps of the synthesis include Wittig homologation, regioselective epoxide ring opening, Sharpless asymmetric epoxidation, Evans aldol reaction, and Yamaguchi macrolactonization.
متن کاملStudies on Carbohydrate Metabolism
Previous studies of carbohydrate metabolism have been limited almost exclusively to naturally occurring saturated sugars. Very little attention has been devoted to the fate of the unsaturated and anhydro sugars in the organism. Even though these unsaturated sugars occur very rarely in nature, information concerning their fate in the body would be of value in determining the mechanism of sugar m...
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ژورنال
عنوان ژورنال: Agricultural and Biological Chemistry
سال: 1977
ISSN: 0002-1369,1881-1280
DOI: 10.1271/bbb1961.41.1689